Paper: Linoleic Acid, a Dietary N-6 Polyunsaturated Fatty Acid, and the Aetiology of Ulcerative Colitis – A European Prospective Cohort Study.
1 University of East Anglia, United Kingdom
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Accepted 6 June 2009
Objective. Dietary linoleic acid, an n-6 polyunsaturated fatty acid, is metabolised to arachidonic acid, a component of colonocyte membranes. Metabolites of arachidonic acid have pro-inflammatory properties and are increased in the mucosa of patients with ulcerative colitis. The aim of this investigation was to conduct the first prospective cohort study investigating if a highdietary intake of linoleic acid increases the risk of developing incident ulcerative colitis.
Design & Setting. Dietary data from food frequency questionnaires were available for 203 193 men and women aged 30-74 years, resident in the UK, Sweden, Denmark, Germany or Italy and participating in a prospective cohort study (EPIC – European Prospective Investigation intoCancer and Nutrition). These participants were followed up for the diagnosis of ulcerative colitis. Each case was matched with four controls and the risk of disease calculated by quartile of intake of linoleic acid adjusted for gender, age, smoking, total energy intake and centre.
Results. A total of 126 participants developed ulcerative colitis (47% women) after a median follow-up of 4.0 years (range 1.7-11.3 years). The highest quartile of intake of linoleic acid was associated with an increased risk of ulcerative colitis (OR=2.49, 95% CI=1.23 -5.07, p=0.01) witha significant trend across quartiles (OR for trend = 1.32, 95% CI=1.04-1.66, p=0.02).
Conclusions. The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis.An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake.
Source: Gut. Published Online First: 23 July 2009. doi:10.1136/gut.2008.169078